PDH Complex: A Catalyst in Cellular Metabolism (P26505)

Target Name: Pyruvate Dehydrogenase Complex

NCBI ID: P26505

Pyruvate Dehydrogenase Complex

Other Name(s): PDH Complex | PDH

PDH Complex: A Catalyst in Cellular Metabolism

Pyruvate Dehydrogenase Complex (PDH Complex) is a protein complex that plays a crucial role in the metabolism of pyruvate, a key intermediate step in the citric acid cycle, also known as the Krebs cycle or TCA cycle. PDH Complex is a multi-subunit protein complex that consists of four subunits: E2, E1, F1, and F2. The subunits of PDH Complex are involved in the catalytic activity of the complex, which includes the conversion of pyruvate to alpha-ketoglutarate, a key step in the citric acid cycle.

The PDH Complex is a critical enzyme in the regulation of cellular metabolism and has been implicated in a wide range of cellular processes, including cell growth, cell death, and cell signaling. The PDH Complex is also a drug target and has been identified as a potential therapeutic target for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

The PDH Complex has been extensively studied for its catalytic activity and its role in cellular metabolism. Several studies have characterized the structure and function of the PDH Complex, providing insights into its mechanism of action and its potential as a drug target.

The PDH Complex is a member of the B-cell factor-1 (BFF-1) superfamily of proteins, which includes a variety of enzymes involved in the regulation of cellular metabolism. BFF-1 proteins are characterized by a conserved sequence motif that includes a catalytic active site, a Rossmann-fold, and a carboxylic acid-rich region.

The PDH Complex consists of four subunits: E2, E1, F1, and F2. The subunits are arranged in a specific order, with the E2 subunit at the N-terminus, the E1 subunit at the C-terminus, the F1 subunit in the middle, and the F2 subunit at the A-terminus. The subunits of PDH Complex are involved in the catalytic activity of the complex, including the conversion of pyruvate to alpha-ketoglutarate.

The PDH Complex is a critical enzyme in the regulation of cellular metabolism, as it plays a crucial role in the citric acid cycle. The citric acid cycle is a central metabolic pathway that is involved in the production of energy from food molecules, including glucose. Pyruvate is the key intermediate step in the citric acid cycle, and the PDH Complex is involved in the conversion of pyruvate to alpha-ketoglutarate, which is then used to produce additional energy in the form of ATP.

The PDH Complex is also involved in the regulation of cellular processes, including cell growth, cell death, and cell signaling. It has been shown to be involved in the regulation of cell proliferation, cell survival, and the response to chemotherapy. The PDH Complex has also been implicated in the regulation of cellular signaling, including the production of reactive oxygen species (ROS) and the detoxification of oxidative stress.

The PDH Complex is a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Cancer cells are known to have altered levels of PDH Complex and to use alternative pathways for energy production, including the G1-2- 3 cycle. This suggests that targeting PDH Complex may be an effective way to inhibit the growth and survival of cancer cells.

In neurodegenerative diseases, PDH Complex has been implicated in the regulation of cellular processes that are important for brain function, including the production of dopamine and the regulation of neurotransmitter release. PDH Complex has also

Protein Name: Pyruvate Dehydrogenase Complex

The "Pyruvate Dehydrogenase Complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Pyruvate Dehydrogenase Complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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